All the public transportation leave and stop in Piazza dei Cinquecento, just in front of the Termini station at 5 minutes walking distance from the hotel;

So in few minute you can take metro or buses to reach easily all the main palces in Rome The underground close at 23.30 durinmg the week but the saturday when it close at 24.00. From Termini Station tyou can also easily reach Fiumicino and Ciampino airoport by train.